that image is photo shopped to give her that look.
For the eyes use the eye makeup from this vid http://www.youtube.com/watch?v=W245_LgsJpc or do the eyes from this one http://www.youtube.com/watch?v=qg-2rDnWCJA
For a manic look on the lips pale pale pink with a thin layer inside of a dark red when there puckered a few times they will blend in a way to look frazzled but not stupid.
Look at these.
For the eyes use the eye makeup from this vid
http://www.youtube.com/watch?v=W245_LgsJpc
or do the eyes from this one
http://www.youtube.com/watch?v=qg-2rDnWCJA
For a manic look on the lips pale pale pink with a thin layer inside of a dark red when there puckered a few times they will blend in a way to look frazzled but not stupid.